Bill passes 28-22 and now awaits Governor Daniels' signature.
Democrats boycotted a right-to-work hearing Monday in the Senate as a sign of protest.
The major news out of the statehouse this week was the passage of right-to-work in the Indiana House of Representatives.
The House voted to pass right-to-work legislation with a 55 to 42 vote.
Indiana House Democrats did not show to the session Tuesday.
The House considered several amendments to the right-to-work bill Monday.
More than four dozen amendments to the House version of right to work could be debated Monday.
A group of union workers gathered Friday evening in Bedford to discuss right to work. No supporters of the legislation were present.
An IU law school professor says companies already in Indiana will benefit most from right-to-work legislation.
The Indiana legislature did not pass any legislation this past week.