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IUPUI Researchers Develop Low-Cost Method To Screen Drugs

By Taylor Haggerty

Posted May 22, 2017

Researchers at the IUPUI School of Science are developing a new method to screen for lethal designer drugs such as fentanyl and synthetic cannabinoids.

The project aims to use a low-cost screening method to produce quicker, more sensitive analyses of blood samples for emergency room physicians treating overdoses.

Forensic and Investigative Sciences Program faculty member Nicholas Manicke says a new screening method is necessary now that new, more complicated designer drugs are being introduced.

"So these are really problematic for forensic toxicology labs, law enforcement, and also clinicians, because we just really don't know much about what's on the market," Manicke says.

Manicke says the primary issue with new drug compounds is their potency.

Patients who have ingested a small amount of fentanyl or synthetic cannabinoids can end up in the hospital, but most testing methods aren't sensitive enough to pick up on smaller doses, making it difficult to analyze what's causing the problem.

"Even if they're having really significant and acute symptoms, the concentrations could be low enough that it's very difficult to expect," he says. "So we've taken this idea of ours, this cartridge, and tried to adapt it so that we can make the sensitivity better."

The screening takes about 30 seconds to complete, and the cartridges used for sampling will cost less than 10 dollars each, making it a fast and inexpensive alternative to traditional testing.

Manicke says the method can be used in DUI cases, as well as post-mortem assessments of overdose patients.

The National Institute on Drug Abuse awarded the project a two-year, $410,000 grant to continue working on the project.

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