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IU Professor Models Cells To Fight Cancer With Math

By Indiana Public Media News Staff

Posted February 15, 2018

An Indiana University professor is on the cutting edge of fighting cancer -- with math.

Paul Macklin is an Associate Professor of Intelligent Systems Engineering at IU. He says mathematics can help model the behavior of cells, which would have serious implications for the study of diseases like cancer.

"We start with models of cells and the forces and move them around. And then we start saying well let's model the cell cycle. Let's have the cell grow and divide into two cells," Macklin says. "Let's have the cell move around in its environment. Let's model the signals and the chemicals in the environment that tell the cells what to do."

Using mathematical models of cell behavior, researchers can input data for cancerous cells and get a better understanding of how those cells will behave.

Macklin says it allows them to predict how certain drugs and treatments will work, without the risks of working with a real patient.

"So these math models give you a way of looking at that complex system from the safety of your computer, and poke and prod and try new things and see what the surprises are before you get surprised in the clinic or an experiment," Macklin says.

In an effort to harness the powers of modeling, Macklin and collaborators created PhysiCell, an open source cell modeling software that anybody can access.

Macklin says he's excited to see how researchers and health professionals make use of modelling tools like PhysiCell.

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