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Opioid Replacement Compound Could Treat Chronic Pain

By Meredith Juliet

Posted March 31, 2017

Indiana continues to battle the opioid epidemic, with drug overdose deaths increasing, but research from Purdue University could help the cause.

Val Watts, Purdue University professor of medicinal chemistry and molecular pharmacology, says he and his team targeted an enzyme, which could ultimately be a non-addictive opioid replacement compound.

"We were able to use that compound in an animal model of inflammatory pain, and showed that it was just as effective as opioids were at relieving inflammatory pain," Watts says.

Watts says this could be a breakthrough that has the potential to tame the opioid epidemic sweeping Indiana and the country.

"Because it does relieve pain it could replace opioids, or it could be used in combination with opioids," Watts says. "So, it would allow you to use a lower dose of the opioid and decreasing your chance of developing dependence by combining compounds like ours with an opioid."

Watts says the compound has been tested in opioid dependent animals and so far, it appears to block the symptoms of dependence.

"Opioids are very rewarding," Watts says. "But our enzyme is not expressed in those brain regions so we don't think our compound is going to be rewarding, or that it may be able to block the reward associated with opioids."

The compound has tests to still undergo and Watts says it could be years before a drug makes it into the consumer marketplace.

"We're not at the drug stage yet, we're a long ways from that," Watts says. "But I think it gives us hope that we found a new target that is not an opioid receptor that we could go after for this type of pain."

The next step for Watts and his team of researchers is to find more funding.

Lindsey Wright contributed to this story.

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Opioid Replacement Compound Could Treat Chronic Pain

By Meredith Juliet

Posted March 31, 2017

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