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IU Researchers To Study Antibiotic Resistant Bacteria

By Indiana Public Media News Staff

Posted February 11, 2015

A team of chemists and biologists have been awarded $3.3 million by the National Institutes of Health to conduct extensive research on antibiotic resistant bacteria.

About two years ago Michael VanNiewenhze and Yvez Brun made a discovery that they hope will help them understand the subject on a new level.

By adding a generated chemical to cells in the form of a dye, they could locate where the bacteria are building their cell walls.

Daniel Kearns, an associate professor of biology at IU and co-investigator on the team calls antibiotic resistance the next big challenge in medicine.

"Some bacteria make us sick and they do so by growing in our bodies," he says. "We take antibiotics to prevent them from growing. And one way we can target them is by interrupting their ability to make this cell wall that surrounds them. Bacteria are very good at evolving new tricks."

Bacteria do so in a number of ways like creating enzymes that destroy the antibiotic, creating pumps that keep the drug concentration low or modifying the target of the drug.

Kearn says that with such a significant grant they will be able to do pretty extensive research on when, where and how the bacteria make this wall. He says the team will be able to remain on the forefront of developing new processes and research.

"In combination with the outstanding imaging technology here at Indiana, we should have unprecedented resolution of how bacteria are building themselves with space and time," he says.

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