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New Drug Shows Promise In Preventing Alzheimer's

By Indiana Public Media News Staff

Posted July 24, 2015

Indianapolis-based Eli Lilly has developed a drug that targets a sticky protein that has been linked to Alzheimer's disease.

The company announced this week at the Alzheimer's Association International Conference in Washington D.C. that its drug solanezumab reduced Alzheimer's progression by 34 percent.

Beta-amyloid build-up in the brain has been well-documented in Alzheimer's patients.

Eli Lilly's drug aims to reduce that build-up. Brain scans of patients who took the drug early on show little to no beta-amyloid plaque.

"It's providing evidence that the drug is actually doing something to delay or interrupt the underlying disease process of Alzheimer's disease," Indiana University neurology professor Martin Farlow says.

Kristi Ritchie, Family and Community Program Coordinator with the Alzheimer's Association of Greater Indiana Chapter, says the research is encouraging, but warns more research into the drug still needs to be done.

"It's not going to be available next week or next month, but it does give people some hope," Ritchie says.

Eli Lilly officials recognized the complexity of Alzheimer's treatment.

"Alzheimer's disease is one of many possible causes of cognitive impairment, which can make diagnosis challenging," Eli Lilly's vice president of clinical development Michael Pontecorvo said in a statement. "These findings provide further support for how knowledge of the presence or absence of amyloid pathology may affect both diagnosis and management in patients being evaluated for Alzheimer's disease or other possible causes of cognitive decline."

The next round of testing is expected to wrap up in 2016.

About 5.3 million Americans have Alzheimer's disease.

Lauren Clark and Network Indiana contributed to this report.

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