Indiana has seen more than 45 human cases of West Nile virus this year, compared to just over ten last year.
The virus, which is transmitted through mosquito bites, can cause fever, headache, body aches, swollen lymph glands or rash.
Non-human West Nile Virus cases have been detected throughout the state, although only one human case has been confirmed.
The health department is urging property owners to insure that there is no standing water on their property, as stagnant water leads to mosquitoes.