The I-65 project between Greenwood and Franklin has caused delays since April 2015.
Police say drivers should avoid the southbound lanes of State Road 37 between Martinsville and Bloomington between noon and 3:30 p.m.
Most of the legislation’s money is short-term or one-time dollars.
The money will pay for improvements on several U.S. and state highways.
Lawmakers from both parties said they were going to make road funding a priority this session.
The road funding debate has led to a strange dynamic, with Republican Gov. Mike Pence and Democrats pushing back against a House GOP plan to raise taxes.
The bill is the result of a two-year review begun after a class-action suit showed millions of dollars in overcharges and undercharges.
A Senate committee unanimously advanced Pence’s proposal, while another Senate committee unanimously approved a bill supported by Pence.
The House plan would divert more money from the sales tax on gasoline into road funding.
The project took more than three years to finish and there are still two more sections of the controversial highway left to be completed.