The drills are planned to give emergency officials, residents, schools and businesses a chance to test and review emergency plans.
Indiana University officials will activate a test drill on each campus throughout the state using IU-Notify.
Monroe County Emergency Management Director Jim Comerford can check each of the 42 sirens in the county with a computer system.
The first test will be activated during the morning between 10:15 and 10:30. The second will take place during the evening between 7:30 and 7:45.