Police say drivers should avoid the southbound lanes of State Road 37 between Martinsville and Bloomington between noon and 3:30 p.m.
Road construction is already scaled back around this time, due to weather effects on operations, making holiday travel a bit easier this season.
The first phase of a $7.3 million project on S.R. 37 in Martinsville begins at 7 p.m. Friday.
A man was hit and killed last month after he tried to cross SR 37 near Martinsville High School.
Indiana State Police say cleaning up a fuel tanker spill from Sunday took longer than expected.