Northern regions of the Hoosier State are seeing up to six inches of snow, the National Weather Service says.
Heavier snowfall amounts are tracking further north leaving south central Indiana with only a trace of snow by Monday.
Transportation departments say they are ready for this year's winter, despite the temperatures dropping early in the season.
Indianapolis has received more than 51 inches of snow since December.
Snow is expected to fall throughout the day on Friday bringing snowfall totals of three to four inches by late afternoon.
Current indications are that 5 to 10 inches of snow will occur as a low pressure system moves from the Gulf of Mexico through the Tennessee and Ohio Valleys.
Homeowners should open storm drains blocked by snow to prevent local flooding.
South central Indiana may see up to 1 inch of snow by midnight.
Power outages are being reported across the area, but the area hardest hit is Vigo County.
Freezing temps affect surrounding counties, causing delays and closures.