The project took more than three years to finish and there are still two more sections of the controversial highway left to be completed.
The trip from Evansville to Bloomington just got shorter by about 18 minutes.
Gov. Mike Pence will gather with local and regional leaders to cut the ribbon on the section of interstate Wednesday morning.
A ceremony is reportedly planned for Dec. 9 to mark the opening of the new section of interstate.
Crews are nearly finished paving travel lanes, meaning they'll soon move on to putting up signs, lighting, guardrails, striping and working on the shoulders.
Officials say they are cautiously optimistic there won’t be any backlash from INDOT for years of opposition to the road from county leaders.