The rate of opioid related admissions to Indiana hospitals and emergency departments has increased dramatically over the past 10 years.
Police say in a statement the overdoses are preliminarily linked to a "tan colored heroin" and spice, a synthetic cannabinoid.
Indiana Attorney General Curtis Hill is working with a coalition of his counterparts to investigate whether opioid manufacturers have broken any laws.
Overdoses caused by multiple types of opioids require larger or repeated doses of naloxone.
Activists say a new drug in Indiana is among the deadliest opioids authorities have seen.
Some officers are now carrying up to three doses of naloxone.
According to the CDC report, the national drug-related death rate has increased more than two and a half times since 1999.
Hogsett kicked off a naloxone training class Thursday in Marion County for homeless outreach providers.
The proposal is a response to the state's growing heroin epidemic.
Muncie health officials administered 21 doses of the overdose antidote Narcan over the first five days of the month.