Temperatures are expected to dip to 12 degrees below zero with a windchill factor making it feel like 30 degrees below zero.
Forecasters say many areas can expect up to ten inches of snow by Saturday morning.
Homeland Security officials say in addition to having a family emergency preparedness plan, homeowners should take steps to protect their property as well.
Water levels in Indiana lakes and reservoirs are still low despite increased rainfall.
A report shows the number of tornadoes in Indiana merits the state's inclusion in "tornado alley."
Meteorologists say the setup is similar to the system that fueled at least 20 tornadoes Wednesday in the Midwest.
In 2011 more than three times the average yearly total of tornadoes hit Indiana.
A meteorologist with the National Weather Service says a statewide policy needs to be put in place.
The most powerful was an EF-3 that touched down near Bedford.
National Weather Service meteorologists say areas of south-central Indiana should prepare for flooding as storms move into Indiana over the next few days.