400 Rolls Royce employees, mostly based in Indianapolis, will lose their jobs.
Multi Packaging Solutions in Terre Haute will close its doors Dec. 31 and lay off 150 employees.
GE workers rallied Thursday in hopes the company would reconsider its decision to lay off 160 workers.
GE announced plans earlier this month to lay off 160 workers from its Bloomington plant.
More than 200 employees at Camp Atterbury in Edinburgh will lose their jobs.
GE officials say demand for its side-by-side refrigerators has fallen by more than 30 percent since 2010, leading to a need for layoffs.
Most of Eli Lilly's employees will not be eligible for pay increases until 2015.
Eli Lilly officials say the cuts come as it loses Cymbalta and Evista brands, which made up about 20 percent of Lilly‘s global corporate revenue in 2012.
The district has seen enrollment decline by about 200 students in the past five years.
Hostess Brands announced Friday it is going out of business after strikers did not return to work Thursday.