Officials say the cuts won't impact the union steelworkers who operate the refinery.
A steelworker was killed at U.S. Steel's Gary Works plant last Friday, making it the second death at the plant this year.
Layoffs can be certified trade-related if workers think they've lost their jobs due to foreign import pressures or their company moves overseas.
Legislators are considering forming a program that would allow businesses to reduce workers' hours instead of laying them off during hard economic times.
400 Rolls Royce employees, mostly based in Indianapolis, will lose their jobs.
Multi Packaging Solutions in Terre Haute will close its doors Dec. 31 and lay off 150 employees.
GE workers rallied Thursday in hopes the company would reconsider its decision to lay off 160 workers.
GE announced plans earlier this month to lay off 160 workers from its Bloomington plant.
More than 200 employees at Camp Atterbury in Edinburgh will lose their jobs.
GE officials say demand for its side-by-side refrigerators has fallen by more than 30 percent since 2010, leading to a need for layoffs.