The game is expected to draw one of the four largest crowds in IU football history.
Indiana doctors are reporting that they are seeing more cases of the respiratory illness, pneumonia this year.
Latham missed the season opener after he and several other players were sidelined for unspecified reasons.
IU's last home non-conference game is Saturday against Western Kentucky.
Officials say the suspensions could have come as punishment for an array of different occurrences.
The 20-year-old safety was dismissed from IU after he was arrested on several felony drug charges in June.
The 10 football players boycotted three games in 1969 after they said they were treated unfairly because of their race.
Indiana University football coaches and team members say they have high expectations for the upcoming season.
The Indiana University football team is seeking to end its season with a win over rival Purdue.
IU Athletics and the Indiana State Police department are advising fans to take alternate routes so they don’t miss kick off.