The annual Hoosiers Outrun Cancer race and the Lotus World Music & Arts Festival will cause detours in downtown Bloomington and on IU's campus.
The bridge closed Aug. 7 after sinking several inches.
A 50-mile stretch of I-65 that runs through Lafayette will remain closed until mid-September.
Hoosiers traveling to Lafayette or Chicago will have to take an alternate route as INDOT works to repair a bridge on I-65.
The road is scheduled to re-open to traffic by the end of November.