Officials say a Miller Transportation bus struck the minivan from behind about 1:45 p.m., triggering a collision involving three other vehicles.
Police say the man was operating a large field sprayer loaded with herbicide when it entered the railroad tracks and was struck by the train.
On Tuesday a turkey crashed through an SUV windshield in Northern Indiana, and Wednesday the same thing happened to a State trooper in Scottsburg.
Indiana State Police officials say it isn't clear what caused the Tuesday afternoon crash near the White County community of Brookston.
Tesla Motors has said it's unlikely its semi-autonomous Autopilot system was engaged when the car crashed in Indianapolis in November.
While the governor meets with top officials from the Centers for Disease Control, proposed ethics reforms are making their way to his desk.
The Megabus was driving on I-65 in Johnson County last Monday when traffic slowed because of construction near Edinburgh.
Indiana State Police say none of the injuries are life threatening.
Megabuses were involved in three crashes in Indiana over the past few months, and another bus was taken out of service Wednesday because of safety concerns.
A stolen car crashed into a Greyhound bus on Sunday, killing the car's driver and injuring 18 bus passengers.