People experiencing homelessness are moving to other areas of the city after increased police patrols in People's Park.
Police responded to five spice-related overdoses over the weekend.
Police say in a statement the overdoses are preliminarily linked to a "tan colored heroin" and spice, a synthetic cannabinoid.
Some local business owners are pleased with the increased police presence, but critics say it fails to address real issues facing the homeless population.
Police responded to two attempted abductions and a total of 387 traffic stops.
Police say two men and one woman kidnapped an adult man and drove him to rural Owen County where they beat him severely and left him tied to a tree.
An Indiana State Police spokesperson says law enforcement's "measured response" to the large protest helped guarantee the rights of all persons involved.
The suspect was described to be wearing a clown mask during the robbery where he allegedly held a semi-automatic handgun to a manager's head.
Police say they used naloxone to revive people in almost every situation.
Bloomington Police Captain Steve Kellams says no officers were on the scene of the protest, but he says they were monitoring the situation.