Despite a city council vote of 4-2 for the ban, some residents say they are not pleased.
The Columbus ordinance is stricter than the state smoking ban that provides exemptions for bars, taverns and private clubs.
Bars, restaurants, hotel rooms and bowling alleys will no longer allow their customers to smoke inside starting June 1st.
The Indiana State Excise Police have begun a pilot program aimed at reducing underage drinking near college campuses.
The Indiana Senate has never passed a smoking ban out of committee. Politicians say this year's bill has bipartisan support.
A statewide smoking ban is headed for a vote in the House next week.
Bar owners say a smoking ban targets their businesses and could hurt their profits.